Tasmanian Devil Facial Cancer breakthrough

Scientists have discovered the true identity of a contagious form of cancer that is killing Tasmanian devils.

The cancer, called devil facial tumor disease, stems from cells that normally insulate nerve fibres, a new study shows.

Save the Tasmanian Devil Program

Genetic analysis of tumors taken from infected devils in different parts of Tasmania reveals that these insulating cells, known as Schwann cells, became cancerous in a single Tasmanian devil and have since passed to other devils, an international group of researchers reports in the Jan. 1 Science.

Previously, scientists had suspected that a virus might be the source of the infection, but the new study confirms that cancer cells themselves are transmitted from devil to devil.

Knowing the origin of the contagious tumors could help conservationists diagnose the disease more accurately and may eventually lead to a vaccine that would target tumor proteins, says Katherine Belov, a geneticist at the University of Sydney who was not involved with the project.

A vaccine against the facial tumor disease, “while now pie in the sky, in 10 years might not be,” says Gregory Hannon, a Howard Hughes Medical Institute investigator at Cold Spring Harbor Laboratory on Long Island, N.Y. “Ten years might be enough time” to save the devils from extinction, he says.

About 70 percent of the Tasmanian devil population has disappeared as a result of the disease, and if the current rate of decline continues, devils could become extinct in the wild in 30 to 50 years, says Elizabeth Murchison, now a postdoctoral researcher at the Wellcome Trust Sanger Institute in Hinxton, England. Murchison, a native of Tasmania who grew up seeing devils in the wild, led the project while working in Hannon’s lab at Cold Spring Harbor. “I didn’t want to sit back and let the devils disappear,” she says.