Amelia Earhart's Finger Bone Recovered

A tiny bone fragment could provide crucial information about the fate of Amelia Earhart, the legendary pilot who disappeared 73 years ago while flying over the Pacific Ocean in a record attempt to fly around the world at the equator.

Collected on Nikumaroro, an uninhabited tropical island in the southwestern Pacific republic of Kiribati, the bone has raised the interest of The International Group for Historic Aircraft Recovery (TIGHAR), which has long been investigating the Earhart mystery, as it may be from a human finger.

The phalax was found together with other artifacts during a month-long expedition last June to the tiny coral atoll believed to be Earhart's final resting place.

"At first we assumed it was from the turtle whose remains we found nearby. Indeed, sea turtles have finger bones in their flippers. But further research suggests it could also be human," Ric Gillespie, executive director of TIGHAR, told Discovery News.

Read more here Amelia Earhart's Finger Bone Recovered? : Discovery News

Vitamin D deficiency confirmed as common across a range of rheumatic conditions

Vitamin D deficiency confirmed as common across a range of rheumatic conditions

Two separate studies have shown that vitamin D deficiency is common in patients with a range of rheumatic diseases, with over half of all patients having below the ‘normal’ healthy levels of vitamin D (48-145 nmol/L) in their bodies.

A further study assessing response to vitamin D supplementation found that taking the recommended daily dose did not normalise vitamin D levels in rheumatic disease patients. The results of these three studies were presented today at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy.

A UK study of 180 patients aimed to assess mean levels of vitamin D in patients with inflammatory joint diseases, osteoarthritis and myalgia (muscle pain that, when experienced long term may be associated with nutritional deficiency).

Data on vitamin D levels were gathered and results showed that 58% of individuals with a rheumatic condition had levels below that clinically considered to be ’sufficient’ in healthy subjects (48-145 nmol/L).

An Italian study of 1,191 RA patients aimed to determine a correlation between vitamin D deficiency and several different clinical measures of disease activity.

Researchers found that, regardless of supplementation, levels of 25-hydroxyvitamin D (25(OH)D), (a standard clinical measure of vitamin D in the blood), were lower than healthy levels (<50 nmol/L) in 85% of the patients not taking a vitamin D supplement and in 60% of those taking 800 IU or more vitamin D daily as a supplement.

In non-supplemented patients levels of 25(OH)D significantly correlated with three measures of disease activity – the Health Assessment Questionnaire Disability Index, (p=0.000) the Mobility Activities of Daily Living Score (p=0.000) and the Number of Swollen Joints count (p=0.000).

“We have seen in studies that vitamin D deficiency is common in patients with a range of rheumatic diseases, and our results have confirmed this using several clinically accepted measures of disease activity,” said Dr. L. Idolazzi, of the Rheumatology Unit, University of Verona, Italy.

“What we need to see now is a range of long term studies, which examine the clinical response of patients to vitamin D supplementation.”

Furthermore, a third study undertaken in Italy aimed to evaluate the affect of vitamin D supplementation in patients with inflammatory autoimmune disease (IAD) and non-inflammatory autoimmune disease (NIAD).

Following supplementation, only 29% patients reached vitamin D levels greater than the level clinically considered to be ’sufficient’ in healthy subjects, with no significant differences in vitamin D levels observed between the IAD and NIAD groups.

“Whilst it is well known that hypovitaminosis D is often seen in patients with inflammatory autoimmune diseases, the effects of supplementation have not been fully investigated in this setting,” said Dr. Pier Paolo Sainaghi of the Immuno-Rheumatology Clinic, A. Avogadro University of Eastern Piedmont, Novara, Italy and author of the third study.

“The results of our study show that daily 800-1,000 IU supplementation is not sufficient to normalise vitamin D levels in patients with rheumatologic or bone conditions. What is unclear is whether a higher dose would be more effective.”